7.3.1 Primary immunodeficiencies
  • Primary (B-cell) antibody deficiency
  • Primary (T-cell) cell-mediated deficiency
  • Phagocyte deficiency (chronic granulomatous disease)
  • SCID (Severe Combined Immunodeficiency Disease
  • Leukocyte Adhesion Deficiency
  • Chediak-Higashi Syndrome
graphic
Fig. 5-35 Simplified scheme of lymphocyte development and sites of block in primary immunodeficiency diseases. The affected genes are indicated in parentheses for some of the disorders. ADA, adenosine deaminase; CD40L, CD40 ligand (also known as CD154); CVID, common variable immunodeficiency; SCID, severe combined immunodeficiency.
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