Pathology
  • Systemic fibrosis:
    • Skin
    • graphic
    • graphic
      • Fig. 5-33 Systemic sclerosis. A, Microscopic appearance in the skin. Note the extensive deposition of dense collagen in the dermis with virtual absence of appendages and thinning of epidermis. B, Advanced systemic sclerosis. The extensive subcutaneous fibrosis has virtually immobilized the fingers, creating a clawlike flexion deformity. Loss of blood supply has led to cutaneous ulcerations. (A, Courtesy of Dr. Trace Worrell, Department of Pathology, University of Texas Southwestern Medical School, Dallas; B, courtesy of Dr. Richard Sontheimer, Department of Dermatology, University of Texas Southwestern Medical School, Dallas.)
    • GI tract
    • Kidneys
    • Heart
    • Muscle
    • Lung
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