Preformed mediators
  • Histamine
    • histamine C5H9N3; a substance produced from the amino acid histidine, which causes dilation of blood vessels, increased secretion of acid by the stomach, smooth muscle constriction (e.g., in the bronchi), and mucus production, tissue swelling, and itching (during allergic reactions).
  • Chemikines
    • Several groups composed of usually 8–10 kD polypeptide cytokines that are chemokinetic and chemotactic stimulating leukocyte movement and attraction. Syn: intercrines.
  • Proteases
    • Descriptive term for proteolytic enzymes, both endopeptidases and exopeptidases; enzymes that hydrolize (break) polypeptide chains.
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