Pathology
  • Kidney
  • Skin
  • Joints
  • Serositis
  • Heart
  • Spleen
  • Lungs
Kidney: glomerulonephritis
graphic
Fig. 5-24 Lupus nephritis. There are two focal necrotizing lesions at 11 and 2 o’clock. (H & E stain.) (Courtesy of Dr. Helmut Rennke, Department of Pathology, Brigham and Women’s Hospital, Boston.)
Skin:
  • Basement membrane thickening
  • Inflammation of sun-exposed areas (butterfly rash)
Joints:
  • Arthritis
  • Synovitis (like Rheumatoid)
    • Inflammation of a synovial membrane, especially that of a joint; in general, when unqualified, the same as arthritis.
Serositis:
  • Inflammation of a serous membrane.
    • Pericardium
    • Pleura
Heart: nonbacterial verrucous endocarditis (Libman-Sacks)
graphic
Fig. 5-23 Libman-Sacks endocarditis of the mitral valve in systemic lupus erythematosus. The small vegetations attached to the margin of the valve leaflet are easily seen. (Courtesy of Dr. Fred Schoen, Department of Pathology, Brigham and Women’s Hospital, Boston.)
Spleen: "onion-skin" pervivascular fibrosis
Lungs:
  • Interstitial pneumonitis
  • Fibrosing alveolitis
Top