Pathology
  • Kidney
    • most common cause of death
    • enlarged, waxy, firm
    • involves primarily glomeruli and also peritubular interstitium, arteries and arterioles
  • Spleen
    • begins perifollicularly
    • two patterns of deposition
      • Sago spleen
        • splenic follicles
        • granular on gross exam
      • Lardaceous
        • deposited in walls of sinuses
        • fusing
  • Liver
    • first observed in space of Disse
    • then hepatic parenchyma
  • Heart
    • interstitial deposits with pressure atrophy of myocytes
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