Clinical
  • Course highly variable
    • Minimal symptoms or rapidly progressive.  Recurrent flares and remissions over many years.  Ten year survival 80% (death due to renal failure or infections).
  • Fever/fatigue
  • Symptoms referable to damage to virtually any organ
  • Butterfly rash on face
  • Discoid lupus erythematosus (DLE)
  • Limited to skin (not systemic LE)
      • Discoid lupus: a form of lupus erythematosus in which cutaneous lesions are present; these commonly appear on the face and are atrophic plaques with erythema, hyperkeratosis, follicular plugging, and telangiectasia; in some instances systemic lupus erythematosis may develop. Syn: chronic discoid lupus erythematosus.
  • Psychiatric disorders
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