Autoimmune hemolytic anemia
1.  cold-antibody type, caused by hemagglutinating antibody (usually IgM class) maximally active at      4°C; and resulting from severe hemolysis in cold hemagglutinin disease;
2. warm-antibody type (which is the most common), acquired hemolytic anemia due to serum      autoantibodies (usually IgG class), maximally active at 37°C, that react with the patient's red blood      cells; it varies in severity, occurs in all age groups of both sexes, and may be idiopathic or      secondary to neoplastic, autoimmune, or other disease.
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